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About two years later, Kevin Esvelt, a geneticist then at Harvard University, put gene drives and Crispr together. Instead of poking a big fat glass needle loaded up with synthetic DNA into every organism that you want to change, you do it once, with a gene drive that encodes not only the gene you want (or the deactivation of the gene you don’t want) but also instructions to do that same manipulation with the Crispr technique in another genome. So when your altered organism mates, its chromosome gets to work, engineering the chromosome inherited from the mate too. This guarantees that the offspring has the desired change, plus the instructions to make the desired change. When the offspring reaches maturity and mates, the process repeats. In a perfect “global” gene drive, 100 percent of offspring have the gene drive carrying the desired trait.
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the C2 wiki.
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